He was surprised to find that the TV set has a basic defect.

他发现那台电视机有个大毛病，非常吃惊。

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Using a basic Defect workflow, they might receive six or seven e-mails based on state changes.

使用一个基本的 Defect 工作流，他们就有可能收到 6 至 7 封基于状态变更的电子邮件。

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At the core of the matter is this: Is this due to high circulating insulin or is it the basic defect associated with both obesity and type 2 diabetes, that is, insulin resistance?

这一问题的关键在于：导致胰岛素与癌症关联的原因到底是血清中高浓度的胰岛素，还是肥胖和2型糖尿病的基础病理生理改变——胰岛素抵抗呢？

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But the Cystic Fibrosis Trust said the medicine was "transformational", had a "dramatic effect" and that experts say "no other medicine addresses the basic genetic defect in cystic fibrosis".

BBC: Cystic fibrosis: New drug Kalydeco refused for Welsh NHS